Products

DRUGACE-P SUSPENSION
For Clear Result in
Pain & Inflammation

Composition:
Each film coated suspension contains:
Aceclofenac 50mg & Paracetamol 125mg

ACECLOFENAC:

It is a phenyl acetic acid derivative showing effective anti-inflammatory and analgesic properties, and a good tolerability profile in a variety of painful conditions. Aceclofenac has been shown to exert effects on many mediators of inflammation. It inhibits synthesis of the inflammatory cytokines interleukin-1b and tumour necrosis factor, and inhibits prostaglandin E2 production. In vitro data indicate inhibition of cyclo-oxygenase by aceclofenac in whole blood assays, with selectivity for COX-2 being evident. A unique feature of aceclofenac’s pharmacology is that it, unlike diclofenac and some other NSAIDs, stimulates glycosaminoglycans (GAG) synthesis.

Indications of ACECLOFENAC:
For the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.

Contra-Indications:
Hypersensitivity, GI bleeding, moderate to severe renal impairment, last three months of pregnancy

Special Precautions:
Patients with GI disease, history of peptic ulceration, cerebrovascular bleeding, ulcerative colitis, Crohn’s disease, systemic lupus erythmatosus, porphyria, hematopoietic or coagulation disorders. The dose should be reduced in patients with mild to moderate hepatic, renal or cardiac function impairment.

Side Effects:
Indigestion, heartburn, dyspepsia, diarrhoea, nausea, abdominal pain and flatulence.

Drug Interactions:
Aceclofenac may increase the plasma conc. of lithium and digoxin. Aceclofenac may inhibit the activity of diuretics. Activity of anticoagulants may be enhanced. Convulsions may occur due to interaction between quinolones and NSAIDs.

PARACETAMOL:

(Acetaminophen)Paracetamol is a valuable central analgesic but weak peripheral anti-inflammatory agent & exhibits good & prompt antipyretic action. It does not stimulate respiration, or alter acid base balance & causes less gastric irritation & have no effect on cellular metabolism or clotting factors. It is not uricosuric.

Indications of PARACETAMOL:
Pain, fever.

Special Precautions:
Renal and hepatic impairment.

Side Effects:
Nausea, Rashes, leukopenia is rare.

Drug Interactions:
Enhances oral anticoagulant activity. Absorption increased by metoclopramide. Absorption reduced by pethidine, propanthline. Alcohol (chronic use) potentiates hepatotoxicity by paracetamol.

Packaging: (30 ml)